專長	Specialties
癌症生物學	Cancer biology
藥物設計	Drug design
結構生物學	Structural biology
細胞訊息傳遞	Signal transduction

畢/肄業學校 School of graduation / non-completion	主修學門系所 Department of major	學位 Degree	起迄年月 Period
高雄醫學大學	醫藥暨應用化學系	博士	2005/09 ～ 2010/06
高雄醫學大學	醫藥暨應用化學系	碩士	2003/09 ～ 2005/06
高雄醫學大學	化學所	學士	1999/09 ～ 2003/06

服務單位 Service Unit	職稱 Position	起迄年月 Period
醫藥科學產業學系	專案助理教授	2020/08 ～ 迄今
蘭花應用學程	執行秘書	2020/08 ～ 迄今

服務學校 Service School	服務單位 Service Unit	職稱 Position	起迄年月 Period
國立中興大學	基因體暨生物資訊研究所	專案助理研究員	2018/03 ～ 2020/07
高雄醫學大學附設醫院	整形外科	博士後研究員	2015/08 ～ 2017/09
高雄長庚醫院	整形外科	博士後研究員	2015/02 ～ 2015/07
國立中興大學	生物科技發展中心	博士後研究員	2013/08 ～ 2014/07
國立中興大學	化學系	博士後研究員	2011/08 ～ 2013/07

Penki V.S. Sashankh, Dorothy Priyanka Dorairaja, Jia-Ying Chen, Yu-Lan Chang, Kuldeep Chan, Ramasamy Karvembu, Ching-Ming Chien*, Sodio C.N.Hsu*, 'Synthesis, in silico and in vitro studies of piperazinyl thiourea derivatives as apoptosis inducer for the treatment of colorectal carcinoma ,' Journal of Molecular Structure, In press, Apr. 2022 . (SCI ) [MOST108-2113-M-037-016]

Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chung Chang, Zi-Lun Lai, Lauren D Hagler, Steven C Zimmerman, Ming-Hon Hou*, 'Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA.,' Journal of the American Chemical Society, 142, 25, Jun. 2020, 11165–11172. (SCIE ) [106-2628-M-005- 001-MY3]

Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-Ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng, Kylene Kehn-Hall, Ming-Hon Hou., 'Structure-Based Stabilization of Non-native Protein−Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design,' Journal of Medicinal Chemistry, 63, 6, Feb. 2020, 3131–3141. (SCIE ) [106-2628-M-005-001- MY3]

Rong-Fu Chen, Chun-Ting Wang, Yu-Hua Chen, Ching-Ming Chien, Sin-Daw Lin, Chung-Sheng Lai, Ching-Jen Wang, Yur-Ren Kuo., 'Hyaluronic Acid-Povidone-Iodine Compound Facilitates DiabeticWound Healing in a Streptozotocin -Induced Diabetes Rodent Model.,' Plastic and Reconstructive Surgery, 143, 5, May. 2019, 1371-1382. (SCIE ) [104-2314-B-037-085-MY3]

Yen-Chung Huang, Jebiti Haribabu, Ching-Ming Chien, Gopal Sabapathi, Chon-Kit Chou, Ramasamy Karvembu, Ponnambalam Venuvanalingam, Wei-Min Ching, Ming-Li Tsai, Sodio C N Hsu., 'Half-sandwich Ru(η6-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity,' Journal of Inorganic Biochemistry,, 194, May. 2019, 74-84.. (SCIE ) [107-2113-M-037- 004]

Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chenc, Yang-Chang Wue, Chon-Kit Choua, Chih-Hua Tsengg, Yeh-Long Chenh, Li- Fang Wang, Chien-Chih Chiu., 'Phytochemical 1 Naphtho[1,2-b]furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer.,' Phytomedicine, 15, 54, Feb. 2019, 109-119. (SCIE ) [105-2311-B-037-001]

Yur-Ren Kuo, Chien-Chang Chen, Yen-Chou Chen, Ching-Ming Chien, 'Recipient Adipose-derived Stem Cells Enhance Recipient Cell Engraftment and Prolong Allotransplant Survival in a Miniature Swine Hind-limb Model.,' Cell Transplantation, 26, 8, Aug. 2017, 1418-1427. (SCIE ) [104-2314-B-037-085-MY3]

Ching-Ming Chien, Yung-Wei Chen, Chien-Chang Chen, Yi-Chia Wu, Shu-Hung Huang, Su-Shin Lee, Cheng-Sheng Lai, Sin-Daw Lin, Ching-Jen Wang, Yur-Ren Kuo, 'Adipose-Derived Stem Cell Modulation of T-Cell Regulation Correlates with Heme Oxgenase-1 Pathway Changes,' Plastic and Reconstructive Surgery, 138, 5, Nov. 2016, 1015-1023. . (SCIE ) [104-2314-B-037- 085-MY3]

Chia-Hung Kuo, Jer-An Lin, Ching-Ming Chien, Chang-Han Tsai,Yung-Chuan Liuc, Chwen-Jen Shieh, 'Formation of amide bond catalyzed by lipase in aqueous phase forpeptide synthesis,' Journal of Molecular Catalysis B: Enzymatic, 129, Jul. 2016, 15-20.. (SCIE ) [104-2221-E-005-061-MY3]

Yur-Ren Kuo*, Ching-Ming Chien, Ming-Jen Kuo,Feng-Sheng Wang, Eng-Yen Huang, 'Endothelin-1 Expression Associated with Lipid Peroxidation and Nuclear Factor-κB Activation in Type 2 Diabetes Mellitus Patients with Angiopathy and Limb Amputation,' Plastic and Reconstructive Surgery, 137, 1, Jan. 2016, 187e-195e.. (SCIE ) [92-2314-B-182A-169]

Rong-Kai Lin, Cho-Han Hsu, Chin-I Chiu, Ying-Ju Lai, Feng-Jie Lai, Ching-Ming Chien*, Chu-Chieh Lin*, 'Syntheses, Structures and Anticancer Activity of NNO-Tridentate Schiff Base Copper(II) Complexes,' Journal of the Chinese Chemical Society, 61, Sep. 2014, 1333-1340. (SCIE ) [101-2113-M-005-010-MY3]

Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Lin, 'Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells,' Toxicon, 56, 4, Sep. 2010, 508-520. (SCIE ) [99-2320-M-037- 008-MY3]

Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Pei-Wen Chuang, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, 'Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway,' European Journal of Pharmacology, 636, 1-3, Jun. 2010, 52-58.. (SCIE ) [98-2320-B-037-008-MY3]

Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Long-Sen Chang, Shinne-Ren Lin*, 'Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra.,' Journal of Natural Products, 72, 10, Sep. 2009, 1735–1740. (SCIE ) [97-2320- M-037-008-MY3]

Ching-Ming Chien, Sheng-Huei Yang, Kuei-Li Lin, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, 'Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells.,' Chemico-Biological Interactions, 176, Oct. 2008, 40-47. (SCI ) [95-2113-M-037- 010]

Ching-Ming Chien, Sheng-Huei Yang, Long-Sen Chang, Shinne-Ren Lin*, 'Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells.,' Clinical and Experimental Pharmacology and Physiology, 35, May. 2008, 1059-1064.. (SCIE ) [95-2113-M-037-010]

Ching-Ming Chien, Sheng-Huei Yang, Chun-Chieh Yang, Long-Sen Chang, Shinne-Ren Lin*, 'Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells.,' Cell Biochemistry and Function, 26, Jan. 2008, 111-118. (SCIE ) [95-2113-M-037-010]

Ching-Ming Chien, Sheng-Huei Yang, Mei-Chin Lu, Long-Sen Chang, Shinne-Ren Lin*, 'Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species-independent mitochondrial death pathway.,' Drug Development Research, 63, 4, Mar. 2005, 219-24. (SCIE ) [93-2113- M-037-003]

林珊夢, 簡啟民, 黃瀞瑩, 孫心慈,侯明宏 , '標靶核殼蛋白非典型蛋白質間交介面開發抗冠狀病毒藥物,' 化學, Vol. 78, No. 4, Dec. 2020, pp. 333-342.

楊子欣( Zi Xin Yang), 侯明宏(Ming-Hon Hou), 簡啟民(Ching-Ming Chien) ,'探討硫酸乙醯肝素與新冠病毒棘蛋白受體結合區作為抗病毒藥物開發位點之 In silico研究: 以台灣清冠一號為例', 2021 年生物醫學工程科技研討會 , Nov. 2021 ,台中.

Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu ,'Phytochemical naphtho[1,2-b] furan-4,5 dione in non-toxic dose inhibit VEGF-mediated cell migration and invasion in human non-small-cell lung cancer', 14th Asia Pacific Federation of Pharmacologists (APFP) , Nov. 2021 , P78 ,Taipei.

Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu ,'Naphtha[1,2-b] furan-4,5-dione exerts antitumor activity in human nonsmall cell lung cancer through regulating topoisomerase II activity and DNA damage response.', 2018 Biomaterials and Controlled Releases Society & Controlled Release Society , Oct. 2018 ,Kaohsiung.

Ching-Ming Chien, Jia-Ning Hsu, and Ming-Hon Hou ,'Structure Modeling of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and its Further Validation by X-ray Crystallization.', The 23rd Biophysics Conference , May. 2018 ,poster.

專利名稱 Patent name	狀態 Status	類別 Category	文號 Registration number	公告年月 Date of announcement
含二吡啶并啡并配位基之銅錯合物	獲證	發明	I464174	2014/12

計畫日期 Project date	計畫分類 Project category	計畫名稱 Project title	擔任職位 Position of employment	計畫編號 Project number	補助單位 Funding organization
2021/8 ~ 2021/12	課程改進與教學型計畫	蘭花產業職能養成	主持人	10B05-2-0-07-1	僅本校
2021/1 ~ 2021/12	課程改進與教學型計畫	蘭花專業實務及學術養成	共同/協同主持人	10B01-2-0-27-1	僅本校
2021/1 ~ 2021/12	其他計畫	探討釕金屬錯合物之核酸鍵結機制與癌症治療應用	主持人	SLH-110-08	其他：台南新樓醫院
2021/1 ~ 2021/12	學術研究計畫(校內補助)	蘭科植物天然成分之抗癌藥物開發與 DNA 結合能力評估	主持人	C1-3-01-12	僅本校

執行期限 Project period	姓名 Name	學位 Degree	計劃名稱 Project title	共同指導教授 Thesis co-advisor
2021/07/01 ~ 2022/02/28	陳子瑋	學士	探討Piperazine衍生物對大腸直腸癌之抗癌活性評估

獲獎時間 Date of award	獎項名稱 Award title	授獎單位 Organization conferring the award
2021/11	最佳論文壁報獎	中華民國生物醫學工程學會
2020/12	第十七屆國家新創獎	財團法人生技醫療科技政策研究中心
2018/03	壁報競賽佳作	中華民國生醫材料及藥物制放學會

日期 Date	主題 Topic	主辦單位 Organizer	時數 Hours
2021/06/09 ~ 2021/06/09	109-1教師社群成果分享會(二)	教師發展組	1
2021/06/02 ~ 2021/06/02	109-1教師社群成果分享會(一)	教師發展組	1
2021/05/31 ~ 2021/05/31	遠距教學的課程互動經營策略	教師發展組	2
2021/04/22 ~ 2021/04/22	PBL要義與課程元素	教師發展組	3
2020/12/18 ~ 2020/12/18	教師教學觀摩第五場	教師發展組	1
2020/11/06 ~ 2020/11/06	110學年度教學實踐計畫撰寫與執行經驗分享	教師發展組	1.5
2020/10/05 ~ 2020/10/05	109年度倫理與社會責任教學經驗分享會 II	教師發展組	2
2020/09/02 ~ 2020/09/02	109學年度長榮大學新進教師研習II	教師發展組	3
2020/09/02 ~ 2020/09/02	多元升等薪傳講座(主題：在有限時間中，如 何兼顧研究產出，順利升等)	教師發展組	1
2020/09/01 ~ 2020/09/01	109學年度長榮大學新進教師研習I	教師發展組	4