簡啟民

簡啟民 助理教授(培力型) (Chien, Ching-Ming)
3358  
cmchien@mail.cjcu.edu.tw  
第二教學大樓 6F (Second Academic Building) T20608  
  •  本學期授課
  •  課表&接見時間
  •  歷年授課資訊
  •  
    Lab 第二教學大樓(Second Academic Building) T20516 實驗室 (5F)-共用  
    VCard
    ORCID https://orcid.org/0000-0002-4922-1571

     專長 Specialties
    專長 Specialties
    癌症生物學 Cancer biology
    藥物設計 Drug design
    結構生物學 Structural biology
    細胞訊息傳遞 Signal transduction

    學歷 Educational Background
    畢/肄業學校
    School of graduation / non-completion
    主修學門系所
    Department of major
    學位
    Degree
    起迄年月
    Period
    高雄醫學大學 醫藥暨應用化學系 博士 2005/09 ~ 2010/06
    高雄醫學大學 醫藥暨應用化學系 碩士 2003/09 ~ 2005/06
    高雄醫學大學 化學所 學士 1999/09 ~ 2003/06

     本校經歷 Experience at CJCU
    服務單位
    Service Unit
    職稱
    Position
    起迄年月
    Period
    醫藥科學產業學系 專案助理教授 2020/08 ~ 迄今
    蘭花應用學程 執行秘書 2020/08 ~ 迄今

     外校經歷 Other School Experience
    服務學校
    Service School
    服務單位
    Service Unit
    職稱
    Position
    起迄年月
    Period
    國立中興大學 基因體暨生物資訊研究所 專案助理研究員 2018/03 ~ 2020/07
    高雄醫學大學附設醫院 整形外科 博士後研究員 2015/08 ~ 2017/09
    高雄長庚醫院 整形外科 博士後研究員 2015/02 ~ 2015/07
    國立中興大學 生物科技發展中心 博士後研究員 2013/08 ~ 2014/07
    國立中興大學 化學系 博士後研究員 2011/08 ~ 2013/07

     國外期刊論文 Papers in foreign journals
    Penki V.S. Sashankh, Dorothy Priyanka Dorairaja, Jia-Ying Chen, Yu-Lan Chang, Kuldeep Chan, Ramasamy Karvembu, Ching-Ming Chien*, Sodio C.N.Hsu*, 'Synthesis, in silico and in vitro studies of piperazinyl thiourea derivatives as apoptosis inducer for the treatment of colorectal carcinoma ,' Journal of Molecular Structure, In press, Apr. 2022 . (SCI ) [MOST108-2113-M-037-016]
    Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chung Chang, Zi-Lun Lai, Lauren D Hagler, Steven C Zimmerman, Ming-Hon Hou*, 'Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA.,' Journal of the American Chemical Society, 142, 25, Jun. 2020, 11165–11172. (SCIE ) [106-2628-M-005- 001-MY3]
    Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-Ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng, Kylene Kehn-Hall, Ming-Hon Hou., 'Structure-Based Stabilization of Non-native Protein−Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design,' Journal of Medicinal Chemistry, 63, 6, Feb. 2020, 3131–3141. (SCIE ) [106-2628-M-005-001- MY3]
    Rong-Fu Chen, Chun-Ting Wang, Yu-Hua Chen, Ching-Ming Chien, Sin-Daw Lin, Chung-Sheng Lai, Ching-Jen Wang, Yur-Ren Kuo., 'Hyaluronic Acid-Povidone-Iodine Compound Facilitates DiabeticWound Healing in a Streptozotocin -Induced Diabetes Rodent Model.,' Plastic and Reconstructive Surgery, 143, 5, May. 2019, 1371-1382. (SCIE ) [104-2314-B-037-085-MY3]
    Yen-Chung Huang, Jebiti Haribabu, Ching-Ming Chien, Gopal Sabapathi, Chon-Kit Chou, Ramasamy Karvembu, Ponnambalam Venuvanalingam, Wei-Min Ching, Ming-Li Tsai, Sodio C N Hsu., 'Half-sandwich Ru(η6-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity,' Journal of Inorganic Biochemistry,, 194, May. 2019, 74-84.. (SCIE ) [107-2113-M-037- 004]
    Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chenc, Yang-Chang Wue, Chon-Kit Choua, Chih-Hua Tsengg, Yeh-Long Chenh, Li- Fang Wang, Chien-Chih Chiu., 'Phytochemical 1 Naphtho[1,2-b]furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer.,' Phytomedicine, 15, 54, Feb. 2019, 109-119. (SCIE ) [105-2311-B-037-001]
    Yur-Ren Kuo, Chien-Chang Chen, Yen-Chou Chen, Ching-Ming Chien, 'Recipient Adipose-derived Stem Cells Enhance Recipient Cell Engraftment and Prolong Allotransplant Survival in a Miniature Swine Hind-limb Model.,' Cell Transplantation, 26, 8, Aug. 2017, 1418-1427. (SCIE ) [104-2314-B-037-085-MY3]
    Ching-Ming Chien, Yung-Wei Chen, Chien-Chang Chen, Yi-Chia Wu, Shu-Hung Huang, Su-Shin Lee, Cheng-Sheng Lai, Sin-Daw Lin, Ching-Jen Wang, Yur-Ren Kuo, 'Adipose-Derived Stem Cell Modulation of T-Cell Regulation Correlates with Heme Oxgenase-1 Pathway Changes,' Plastic and Reconstructive Surgery, 138, 5, Nov. 2016, 1015-1023. . (SCIE ) [104-2314-B-037- 085-MY3]
    Chia-Hung Kuo, Jer-An Lin, Ching-Ming Chien, Chang-Han Tsai,Yung-Chuan Liuc, Chwen-Jen Shieh, 'Formation of amide bond catalyzed by lipase in aqueous phase forpeptide synthesis,' Journal of Molecular Catalysis B: Enzymatic, 129, Jul. 2016, 15-20.. (SCIE ) [104-2221-E-005-061-MY3]
    Yur-Ren Kuo*, Ching-Ming Chien, Ming-Jen Kuo,Feng-Sheng Wang, Eng-Yen Huang, 'Endothelin-1 Expression Associated with Lipid Peroxidation and Nuclear Factor-κB Activation in Type 2 Diabetes Mellitus Patients with Angiopathy and Limb Amputation,' Plastic and Reconstructive Surgery, 137, 1, Jan. 2016, 187e-195e.. (SCIE ) [92-2314-B-182A-169]
    Rong-Kai Lin, Cho-Han Hsu, Chin-I Chiu, Ying-Ju Lai, Feng-Jie Lai, Ching-Ming Chien*, Chu-Chieh Lin*, 'Syntheses, Structures and Anticancer Activity of NNO-Tridentate Schiff Base Copper(II) Complexes,' Journal of the Chinese Chemical Society, 61, Sep. 2014, 1333-1340. (SCIE ) [101-2113-M-005-010-MY3]
    Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Lin, 'Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells,' Toxicon, 56, 4, Sep. 2010, 508-520. (SCIE ) [99-2320-M-037- 008-MY3]
    Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Pei-Wen Chuang, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, 'Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway,' European Journal of Pharmacology, 636, 1-3, Jun. 2010, 52-58.. (SCIE ) [98-2320-B-037-008-MY3]
    Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Long-Sen Chang, Shinne-Ren Lin*, 'Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra.,' Journal of Natural Products, 72, 10, Sep. 2009, 1735–1740. (SCIE ) [97-2320- M-037-008-MY3]
    Ching-Ming Chien, Sheng-Huei Yang, Kuei-Li Lin, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, 'Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells.,' Chemico-Biological Interactions, 176, Oct. 2008, 40-47. (SCI ) [95-2113-M-037- 010]
    Ching-Ming Chien, Sheng-Huei Yang, Long-Sen Chang, Shinne-Ren Lin*, 'Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells.,' Clinical and Experimental Pharmacology and Physiology, 35, May. 2008, 1059-1064.. (SCIE ) [95-2113-M-037-010]
    Ching-Ming Chien, Sheng-Huei Yang, Chun-Chieh Yang, Long-Sen Chang, Shinne-Ren Lin*, 'Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells.,' Cell Biochemistry and Function, 26, Jan. 2008, 111-118. (SCIE ) [95-2113-M-037-010]
    Ching-Ming Chien, Sheng-Huei Yang, Mei-Chin Lu, Long-Sen Chang, Shinne-Ren Lin*, 'Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species-independent mitochondrial death pathway.,' Drug Development Research, 63, 4, Mar. 2005, 219-24. (SCIE ) [93-2113- M-037-003]

     國內期刊論文 Papers in domestic journals
    林珊夢, 簡啟民, 黃瀞瑩, 孫心慈,侯明宏 , '標靶核殼蛋白非典型蛋白質間交介面開發抗冠狀病毒藥物,' 化學, Vol. 78, No. 4, Dec. 2020, pp. 333-342.


     國內會議論文 Papers in domestic conferences
    楊子欣( Zi Xin Yang), 侯明宏(Ming-Hon Hou), 簡啟民(Ching-Ming Chien) ,'探討硫酸乙醯肝素與新冠病毒棘蛋白受體結合區作為抗病毒藥物開發位點之 In silico研究: 以台灣清冠一號為例', 2021 年生物醫學工程科技研討會 , Nov. 2021 ,台中.
    Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu ,'Phytochemical naphtho[1,2-b] furan-4,5 dione in non-toxic dose inhibit VEGF-mediated cell migration and invasion in human non-small-cell lung cancer', 14th Asia Pacific Federation of Pharmacologists (APFP) , Nov. 2021 , P78 ,Taipei.
    Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu ,'Naphtha[1,2-b] furan-4,5-dione exerts antitumor activity in human nonsmall cell lung cancer through regulating topoisomerase II activity and DNA damage response.', 2018 Biomaterials and Controlled Releases Society & Controlled Release Society , Oct. 2018 ,Kaohsiung.
    Ching-Ming Chien, Jia-Ning Hsu, and Ming-Hon Hou ,'Structure Modeling of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and its Further Validation by X-ray Crystallization.', The 23rd Biophysics Conference , May. 2018 ,poster.


     專利 Patent
    專利名稱
    Patent name
    狀態
    Status
    類別
    Category
    公告年月
    Date of announcement
    含二吡啶并啡并配位基之銅錯合物 獲證 發明 2014/12

     研究計畫 Research project
    計畫日期
    Project date
    計畫分類
    Project category
    計畫名稱
    Project title
    擔任職位
    Position of employment
    2021/8 ~ 2021/12 課程改進與教學型計畫 蘭花產業職能養成 主持人
    2021/1 ~ 2021/12 課程改進與教學型計畫 蘭花專業實務及學術養成 共同/協同主持人
    2021/1 ~ 2021/12 其他計畫 探討釕金屬錯合物之核酸鍵結機制與癌症治療應用 主持人
    2021/1 ~ 2021/12 學術研究計畫(校內補助) 蘭科植物天然成分之抗癌藥物開發與 DNA 結合能力評估 主持人


     指導學生參與科技部或其他政府機構專題研究計劃 Student advisee participation in independent research projects of the Ministry of Science and Technology or other
    執行期限
    Project period
    姓名
    Name
    學位
    Degree
    計劃名稱
    Project title
    2021/07/01 ~ 2022/02/28 陳子瑋 學士 探討Piperazine衍生物對大腸直腸癌之抗癌活性評估


     研究榮譽獎項-全國性或國際性學術榮譽獎 National or international honorary academic awards
    獲獎時間
    Date of award
    獎項名稱
    Award title
    授獎單位
    Organization conferring the award
    2021/11 最佳論文壁報獎 中華民國生物醫學工程學會
    2020/12 第十七屆國家新創獎 財團法人生技醫療科技政策研究中心
    2018/03 壁報競賽佳作 中華民國生醫材料及藥物制放學會


     研習證明 Proof of study
    日期
    Date
    主題
    Topic
    主辦單位
    Organizer
    時數
    Hours
    2021/06/09 ~ 2021/06/09 109-1教師社群成果分享會(二) 教師發展組 1
    2021/06/02 ~ 2021/06/02 109-1教師社群成果分享會(一) 教師發展組 1
    2021/05/31 ~ 2021/05/31 遠距教學的課程互動經營策略 教師發展組 2
    2021/04/22 ~ 2021/04/22 PBL要義與課程元素 教師發展組 3
    2020/12/18 ~ 2020/12/18 教師教學觀摩第五場 教師發展組 1
    2020/11/06 ~ 2020/11/06 110學年度教學實踐計畫撰寫與執行經驗分享 教師發展組 1.5
    2020/10/05 ~ 2020/10/05 109年度倫理與社會責任教學經驗分享會 II 教師發展組 2
    2020/09/02 ~ 2020/09/02 109學年度長榮大學新進教師研習II 教師發展組 3
    2020/09/02 ~ 2020/09/02 多元升等薪傳講座(主題:在有限時間中,如 何兼顧研究產出,順利升等) 教師發展組 1
    2020/09/01 ~ 2020/09/01 109學年度長榮大學新進教師研習I 教師發展組 4

    長榮大學 深耕在地,連結國際,成為社會責任領航大學

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    No.1,Changda Rd.,Gueiren District, Tainan City 71101, Taiwan(R.O.C.)


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